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Arenas Weight Loss Drug Lorcaserin Rejected By Fda Panel

  • Posted on September 25, 2017 at 4:47 pm

The FDA Endocrinologic and Metabolic Drugs Advisory Committe turned down Arena Pharmaceutical and its partner Eisais propose for the weight-loss drug lorcaserin, based on a 9 to 5 vote against it. Arena shares fell nearly 40 percent in after-hours trading Thursday to $2.28.

The expert panel was not convinced that the current data could adequately demonstrate the potential benefits of lorcaserin outweighing the potential risks when used long-term in a large population of overweight and obese individuals.

The panelists raised concerns similar to that released by FDA staff earlier this week, mainly the results from Arenas Phase III clinical study did not meet mean efficacy criterion. The BLOOM trial indicated that patients on lorcaserin lost an average of 5.8% of body weight compared with 2.2% in the placebo arm. The expert panel also noted that studies of lorcaserin on rodent model showed breast tumours among those dosed at seven times higher than the proposed clinical dose for humans, but acknowledged that no such increase was seen in the 7,000 patients treated with the drug.

The committe called for more studies to be conducted in people with diabetes, high blood pressure and other health problems, therefore the trial result could reflect patients better if it was approved.

I just couldnt get over that we didnt have a broader population that was representative of people most likely to get this (drug), said Dr. Lamont Weide, an advisory panel member and chief of diabetes and endocrinology at the University of Missouri in Kansas City.

Arena was not totally downbeat after the news; Arena and Eisai believe that lorcaserin has a positive benefit-risk profile, said Arenas president and CEO, Jack Lief, in a statement. Eisai will sell lorcaserin in the US if the drug wins FDA approval. Arena will work closely with the FDA going forward, Lief said. The company has been studying lorcaserin in overweight and obese diabetics and said it expects results later this year.

The FDA will make its verdict by October 22, and usually FDA would follow panel recommendations.

Arena, Vivus and Orexigen are three companies struggling to win the first approval of a new weight-loss drug since Roches Xenical in 1999. Vivus Qnexa failed to gain the support from the EMDAC with a voted 10-6 against it; Orexigens Contrave (sustained-release naltrexone/bupropion) is scheduled to face the panels judgement later this year.

Ganhe Dinheiro Na Internet Com 20$2surf

  • Posted on September 25, 2017 at 4:18 pm

It’s easy to make money online.

There is truth to the fact that you can start making money on the Internet as soon as you’re done with this article. After ganhando dinheiro na all, so many others are making money online, why not you? Keep your mind open and you can make a lot of money. As you can see, there are many ways to approach the world of online income. With various streams of income available, you are sure to find one, or two, that can help you with your income needs. Take this information to heart, put it to use and build your own online success story.

fee to watch your webinar at their convenience.

Once it is in place, promotion and possibly answering questions will be your only tasks.

Getting paid money to work online isn’t the easiest thing to do in the world, but it is possible. If this is something you wish to work with, then the tips presented above should have helped you. Take some time, do things the right way and then you can succeed. Start your online today by following the great advice discussed in this article. Earning money is not as hard as it may seem, you just need to know how to get started. By choosing to put your right foot forward, you are heading off to a great start earning money to make ends meet.

Make money online by selling your talents. Good music is always in demand and with today’s technological advances, anyone with musical talent can make music and offer it for sale to a broad audience.

By setting up your own website and using social media for promotion, you can share your music with others and sell downloads with a free PayPal account.

Science Definitions – How to Make Soap

  • Posted on September 25, 2017 at 11:52 am

Before you begin making homemade soap you may want to learn some science definitions. Why is it important? There is a science behind making soap. Some chemicals can be very potent and caution should be heeded. Homemade soap goes through a process of soap formation called saponification. Do you know what saponification means? If you studied science definitions you would know the answer. There is chemistry involved in learning how to make soap. Chemicals are reacting with each other and can be very potent. If you do not understand how chemicals react or the properties they contain then you will have difficulty, for certain, making homemade soap.

Chemicals such as lye, essential oils, glycerin, natural extracts, soap making oils and more should all be understood and used with caution. One example, before working with lye, proper safety precautions should be used. Lye can cause very serious burns if it directly contacts the skin. What should you do if lye does contact the skin or any area surrounding your soap making project? If you knew your science definitions you would know the answers to these very important questions. Knowing these ingredients will, also, be beneficial for making your homemade soap recipes.

Making homemade soap can be a lot of fun, but it does have an expense just like any other hobby or project. If you knew your science definitions, you could save time and money. Are there certain ingredients you would like to know about? Learn with science definitions or science terms.

The reason most people make their own homemade soap is because they know it is healthier for their skin than modern, commercial, soap! How is it healthier? Do you know what parabens are? If you knew your science definitions you would understand the dangers of parabens, found in most commercial soaps! You would, also, learn of homemade soaps and many other homemade skin care products made with a paraben-free preservative!

Take time and learn science definitions, science facts, science terms, science lessons and, even, fun science trivia about making homemade soap! You will be learning from a master soap maker who teaches soap making classes, soap demonstrations, soap workshops and more throughout the southeast USA! You can, even, see soap science and saponification in progress by watching a clip from a soap making DVD! This DVD has step-by-step, easy, soap making instructions! You can learn an abundance of soap making information!

Before you begin making homemade soap, stop, and take time to learn the science facts. Learning science definitions can be your starting point for learning how to make soap! Get started! Have fun making your very own homemade soap!

hangover 2′ Monkey Is Now Addicted To Cigarettes

  • Posted on September 25, 2017 at 9:14 am

Director Todd Phillips has come under fire by animal rights groups for getting the monkey that stars in Hangover 2 addicted to cigarettes.

Todd Phillips has admitted that the monkey, which features in the forthcoming comedy, has become addicted to cigarettes following filming.

Statement from Todd Phillips:

This was a joke. I make comedies.

If you read the story, it doesn’t even make sense. “On the set of her new film, she won’t stop smoking cigarettes”. Umm. Really? Maybe just take them away from her. Or at least take her money away so she can’t buy them any longer.

When you are doing press for a film, it tends to get repetitive, lots of the same questions over and over. Sometimes I like to mix it up with the journalists. Obviously, the monkey in the film NEVER smoked a single cigarette. There are people on set whose sole job is to protect that monkey. Even if I wanted her to smoke it wouldn’t be allowed. By the way, she also appears to do cocaine in the movie, but I guarantee you that she didn’t do that either (I can’t, however, comment on Ken Jeong’s cocaine use in the film).

Sorry for the confusion, but it definitely is a funny headline “PETA pissed after Todd Phillips gets Hangover 2 monkey addicted to cigarettes.” Definitely one for the office wall.

The monkey plays a significant role in the movie. A trailer featuring the primate simulating a sex act was pulled from theaters by the Motion Pictures Association of America earlier this month. (It was re-edited before making a second debut ahead of Scream 4 Friday.)

This isn’t the first time The Hangover’s monkey has come under the spotlight.

The initial trailer for the film, which showed controversial scenes featuring the animal, was pulled by the Motion Picture Association of America after it attracted a host of complaints.

However the monkey has continued to feature heavily in promotional material and trailers for the film, which again stars Bradley Cooper, Zach Galifianakis, and Ed Helms.

The movie takes place two years after the first film which was set in Las Vegas, and features the boys throwing a bachelor party for Stu.

Once again, things don’t go to plan and the trio wake up in a Bangkok hotel room with Ed’s character Stu waking up with a tattoo on his face and Stu’s brother-in-law Teddy missing.

During the mission to find Teddy, the trio visit a monastery where Alan gets knocked out by a monk, a girly bar where gun fire breaks out and yet another car chase where the boys trash a sports car.

Wedding decoration games for girls,dreaming about you own wedding ceremony

  • Posted on September 25, 2017 at 8:58 am

Hey,girls,what’s your dreaming wedding ceremony,and now you have the chance to design and decorate your own wedding scene,how to decorate,and what will be the best look of it,you can have a try and do your best to make it full of colorful things or just to be the most simple and romantic ones,and you can also change the background,that you can have your wedding ceremony one the grass or just at the seaside or under the moonlight,which will also be very romantic then.what do you think about this kind of decoration games for girls.

Okay,let us have a look of all the decoration there,which offers to you,you can just make it to be your best choice and also be the best decoration in the games for girls.and you can play this decoration games for girls,just looks this as your own wedding ceremony ,and you can do whatever you want,of course,as well as what you want to make it to be in your dreaming world too.

Firstly,you can choose the furnishing that you want to own,wow,they are all so beautiful,and will be the best choice for your wedding ceremony,you will have so many kinds of funishing for you to choose then,can’t help watiting for a minute,just come one,and choose for yourself in the girls games.for more furnishing,you can click the arrow,and you can have the chance to see the wonderful design!

You know,if you want to have a wonderful wedding ceremony,you have so many things that you should do then,for example,the food,the arch and also all kinds of decoration that you need in the wedding ceremony decoration games for girls.

Enjoy it,and enjoy your life,just to be happy in your own life,you will find that all the things that you are dreaming can come true,so just have fun from the funny girls games here.

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Earnings Fall 22% Pawnshops Because Kraft

  • Posted on September 25, 2017 at 8:37 am

Mortgage PT (Persero) recorded a decrease in net income to Rp 718 billion in the first half of 2013. The number is down about 22% when compared with net income in the same period of the previous year of Rp 929 billion. Profit decline was due to a continued decline in the price of gold on the market.

“The decline in gold prices greatly affect the performance of the company’s significant because when the price of gold fell Mortgage loan disbursement will face obstacles because its value will go down as the price of gold down,” said Director of Mortgage Finance Agus Dwi Pramoedya when met at the Central Office Pawn Kramat, Jakarta, Thursday (01/08/2013).

However, he said, although besih profit declined but remains the company’s turnover rose. In the first half of this year, the company’s revenue still grew by 6.5% to Rp 4.1 trillion over the same period the previous year which only Rp 3.8 trillion.

Total assets also go up to Rp 33 trillion in the first half of 2013, an increase of 13% when compared to its total assets in the same period the previous year which reached Rp 29.1 trillion.

From the business side, Pawn is able to achieve a turnover in the pawning business of gold amounting to Rp 46 trillion in the first half of 2013, an increase of 6% from the same period last year of Rp 43 trillion.

“It is conventional. If sharia as of June 2013 was Rp 6 trillion, Rp 5.5 trillion last year finished up 8.6%,” he said.

In addition, the company’s customers also increased 15% to 14.4 million in the first half of 2013, when compared to the same period of the previous year which only 13.7 million.

“Seeing this increase, we believe the mortgage business will continue to grow,” he said.

Creating A Green Atmosphere In Hospital

  • Posted on September 25, 2017 at 8:11 am

The great environment would really influence the healing process of the patients. It could increase the health of the patients not only physically, but also emotionally. The effort to create the friendly environment could be by adding some new facilities and improving the old buildings in the hospital. The green solutions to cheer the patients in the hospital are also about the decoration and the construction that are suitable with the green atmosphere.

Step 1

The first step is the protection from any high toxin chemical that could be dangerous to the respiratory of the patients. You could apply the safer cleaning product to avoid the risk by choosing the low toxin product. It also would be very good to use the organic cleaners which have no toxic. Also, you could select the high quality furnishings, adhesives, and also the paints that are absolutely safe with no irritating odors and toxic.

Step 2

To create the green hospital, you could do some effort such as improving the indoor lighting. It is useful to deliver the cheerful situation and decrease the stress level of the people inside the hospital. You could let the sunlight comes to the room of the patients by providing the larger windows. The sunlight is really useful to save the energy and improve the healing process of the patients.

Step 3

You could perfectly apply the green solution by reusing some shipping and packing materials. Also, recycling the plastics, paper, bottles, and other products that could be recycled would be the great effort to green the hospital. However, if you want to create the green hospital effectively, you should eliminate the use of dangerous contaminates.

Step 4

Create the healing garden in the hospital that must be the beautiful place to cheer the patients. It is also really useful to provide the herbal food if the staff could cook the plants provided in the herbal garden.